These capsules contain a complete mix of precursors which trigger the body?s own in-built mechanism to produce natural hormones acting as a catalyst for the desired male to female chemical transformation. The delicate balance of precursor levels in this powerful formula can be adversely affected by caffeine or alcohol. You should not consume either within 2 hours of taking the once-a-day medication. Take one capsule with water before retiring each night. Because of their action on the bodys own ability to produce natural hormones, this medication is perfectly safe to take EXCEPT if you are taking an SSR1 medication such as Prozac or Valium normally prescribed for  depression.